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Neurological Care:New Cannabis Studies Reveal Benefits


In 2013, the spotlight turned to high-CBD strains like Charlotte’s Web for their groundbreaking potential to treat severe epileptic seizures in children. These media stories, driven by the remarkable recovery of a five-year-old girl using cannabis oil, significantly boosted public support for medical cannabis access, advancing the ongoing cannabis legalization efforts.

While cannabis is now frequently discussed for its benefits in pain relief, nausea, and sleep disorders, its promise in treating various neurological health conditions continues to capture scientific interest.

Researchers are delving into the therapeutic potential of cannabis components for conditions such as epileptic seizures, traumatic brain injuries, and neurodegenerative diseases like Alzheimer’s, Parkinson’s, and Huntington’s diseases.

Neurological Care

Lamacoppa Leaf Sciences recently highlighted four newly published papers on this topic, including two comprehensive research reviews and two original studies. These papers shed light on the current scientific landscape and underscore the need for further research.

Beyond Cannabinoids

Researchers from the University of Adelaide, Scott Smid and John Staton Laws III, published a review in Phytomedicine exploring the neuroprotective effects of various cannabis-derived phytochemicals, including cannabinoids, terpenes, flavonoids, and antioxidants. Cannabis sativa produces a vast array of secondary metabolites—over 140 terpenes, 104 cannabinoids, and 26 flavonoids—with diverse biological activities.

Remarkably, cannabinoids like CBD, CBC, Delta-8 THC, and Delta-9 THC, along with terpenes such as limonene, myrcene, and linalool, and the flavonoid cannflavin A, have demonstrated neuroprotective properties in preclinical studies.

These compounds, including terpenes and flavonoids, exhibit antioxidant activity, helping to neutralize free radicals that can damage cells. Although these findings are preliminary, they suggest that cannabis constituents could serve as neuroprotectants, supporting the use of medical cannabis for neurodegenerative diseases.

Focus on CBD

A recent review in the journal Molecules emphasizes CBD’s potential to reduce neuroinflammation through its interaction with microglia, the immune cells of the central nervous system. Given that many neurological disorders are characterized by brain inflammation, cannabinoids like CBD may help in preventing or treating these conditions by modulating the inflammatory response.

Clinical and preclinical evidence indicates that CBD has significant therapeutic potential for epilepsy, multiple sclerosis, ischemic brain injuries, neuropathic pain, schizophrenia, and Alzheimer’s disease.

However, the exact molecular mechanisms by which CBD affects neuroinflammation remain complex and not fully understood. The Food and Drug Administration (FDA) has shown increasing interest in these findings, underscoring the importance of rigorous clinical studies to validate these effects.

Supporting Full-Spectrum Extracts

Recent studies from Italy and Spain further explore the neuroprotective potential of various cannabis constituents. A study published in Frontiers in Pharmacology evaluated the antioxidant and neuroprotective activities of extracts from the Futura 75 hemp strain in mouse brain cells.

The findings suggested that these extracts, rich in cannabinoids, terpenes, and flavonoids, could benefit human health, particularly concerning neurodegenerative disorders.

Similarly, research published in Fitoterapia assessed another full-spectrum cannabis extract’s neuroprotective effects, reinforcing the idea that whole-plant extracts might be more effective than isolated components.

This concept, known as the entourage effect, suggests that the combined action of various cannabis compounds is more potent than their isolated effects.

Health Benefits of Cannabinoids and Terpenes

Cannabinoids and terpenes, the primary chemical compounds found in cannabis, are being extensively studied for their health benefits. Cannabinoids include well-known compounds like THC and CBD, as well as lesser-known ones like CBC and CBG. These cannabinoids interact with the body’s endocannabinoid system to produce various effects, including pain relief, reduction of inflammation, and neuroprotection.

Terpenes, which give cannabis its distinctive aroma, also contribute to its therapeutic effects. For example, limonene has been shown to have anti-anxiety and anti-depressant properties, while myrcene has muscle relaxant and sedative effects.

Antioxidant Activity and Cardiovascular Health

The antioxidant activity of cannabis compounds plays a crucial role in their health benefits. Antioxidants help neutralize free radicals, which are unstable molecules that can damage cells and contribute to aging and diseases, including cardiovascular disease.

Studies showing the effects of cannabis on blood vessels indicate that cannabinoids can improve vascular health by reducing inflammation and oxidative stress. This has significant implications for the prevention and treatment of cardiovascular diseases, which are often linked to chronic inflammation and oxidative damage.

Long-Term Benefits and Chronic Pain Management

One of the most promising areas of cannabis research is its potential for managing chronic pain. Chronic pain affects millions of people worldwide and is often difficult to treat with conventional medications. Cannabis, with its wide range of active compounds, offers a potential alternative.

Clinical studies have shown that cannabinoids can reduce pain and improve quality of life in patients with various chronic pain conditions. The long-term benefits of cannabis use for pain management are still being studied, but early results are promising.

In conclusion, ongoing research highlights the extensive therapeutic potential of cannabis and its constituents for various neurological conditions. As our understanding deepens, the role of cannabis in treating these disorders is likely to become increasingly significant. With continued support from regulatory bodies like the FDA and a growing body of scientific evidence, the future of cannabis in medicine looks bright.

Scientific Evidence

Evaluating Cannabis sativa L.’s neuroprotection potential: From bench to bedside

The Neurotherapeutic Arsenal in Cannabis sativa: Insights into Anti-Neuroinflammatory and Neuroprotective Activity and Potential Entourage Effects

The Dynamic Role of Microglia and the Endocannabinoid System in Neuroinflammation

Evaluation of two different Cannabis sativa L. extracts as antioxidant and neuroprotective agents

Investigation on the neuroprotective effect of a cannabidiol-enriched non-psychotropic Cannabis sativa L. extract in an in vitro model of excitotoxicity.

For more information, visit our Lamacoppa Leaf Sciences Blog.

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