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CBD Isolate THC Free | COSMOS CERTIFIED - CBG Isolate Powder THC Free | COSMOS CERTIFIED

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CBD Isolate Powder

Introducing our elite CBD Isolate, a standout product crafted by the experts at Lamacoppa Leaf Sciences. At the heart of this product is Cannabidiol (CBD), a distinctive cannabinoid known for its unique benefits. Our ability to produce such a high-quality CBD isolate places us among the few who can offer this rare gem in the cannabinoid market.

Crafted through a sophisticated extraction process, our CBD Isolate Powder starts with select hemp, naturally abundant in CBD. We then employ our proprietary techniques to refine and purify CBD, culminating in a superior crystalline white powder that is over 99% pure CBD extract.

Highlights of Our CBD Isolate Powder:

– Immaculate Crystalline Appearance: Our isolate is a testament to purity, presented in a striking white crystalline form that signifies unmatched quality.

– Flexible Integration: Designed for easy incorporation, our CBD Isolate can enhance your products without compromising their original characteristics.
 
– Pure and Untainted: With no discernible taste or smell, our isolate ensures your products maintain their intended flavor and aroma profiles.
– Guaranteed Non-Psychoactive: Benefit from the properties of CBD without any psychoactive effects.
 

– Certified Quality: Subjected to stringent testing by independent labs, our CBD Isolate Powder is verified for its exceptional purity and safety standards.CBG Isolate Powder

CBG Isolate Powder

Discover the pinnacle of purity with our CBG Isolate Powder, a premium offering from Lamacoppa Leaf Sciences. This exceptional product emerges from the rare and valuable Cannabigerol (CBG), a minor cannabinoid celebrated for its unique properties.

Our expertise allows us to harness the power of CBG, yielding a product that stands out in a market where only a select few can produce such a refined isolate.

Our CBG Isolate Powder is the result of a meticulous extraction process, starting with hemp naturally rich in CBG. Through our advanced proprietary techniques, we isolate and purify CBG to achieve a crystalline white powder that boasts an impressive purity level of over 98% CBG extract.

Key Features of Our CBG Isolate Powder:

– Pure Crystalline Form: Our CBG Isolate Powder presents itself as a flawless white crystalline substance, embodying purity and quality.

– Versatile Formulation: Seamlessly integrate our CBG Isolate Powder into your existing product lineup, enhancing them without altering their essence.

-Neutral Sensory Profile: Free from any taste or odor, our CBG Isolate ensures the integrity of your products’ sensory experiences.

– Non-Psychoactive: Enjoy the benefits of CBG without any psychoactive effects, ensuring a pure and focused experience.

– Quality Assurance: Rigorously tested by independent third-party laboratories, our CBG Isolate Powder meets the highest standards of purity and safety.

Elevate your offerings with Lamacoppa Leaf Sciences’ CBD and CBG Isolate Powder, where purity meets innovation.

Lamacoppa Leaf Sciences’s Cannabidiol (CBD), Cannabigerol (CBG) natural isolates , are certified cosmetic raw materials under the COSMOS-STANDARD and approved for use in organic and natural cosmetics products certified to the COSMOS-STANDARD.

Raw material approved for use in cosmetics products certified to the COSMOS-standard.

The COSMOS-standard signature is a trusted consumer guarantee for organic and/or natural cosmetics.

In the EU Cosmetics Ingredient Database, those cannabinoids are indicated as antioxidant or antiseborrhoeic, for skin conditioning and skin protection.

100% natural and contains no artificial flavor, chemical additives, any pesticides, bacterial or microbial organisms, toxins and heavy metals.

As described In the EU Cosmetics Ingredient Database Cannabis Sativa Leaf Extract is the extract of the leaves of Cannabis sativa, Cannabaceae.

The CBD powder and CBG powder can be dissolved in alcohols, alkanes, aromatic hydrocarbon, chlorinated solvents, or polar aprotic solvents.

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Our Raw material

  • Considered GMO-free in accordance with Regulation (EC) No. 1829/2003 & Regulation (EC) No. 1830/2003
  • Considered BSE/TSE free in accordance with Regulation (EC) No. 999/2001
  • Have not been subjected to Animal Testing in accordance with Article 18 of Regulation (EC) No. 1223/2009
  • Comply with Regulation (EC) No. 1907/2006 or Regulation (EC) No. 987/2008 (REACH)
  • Do not contain substances classified as carcinogenic, mutagenic, or toxic for reproduction (CMR) in accordance with Article 15 of Regulation (EC) No. 1223/2009
  • Do not contain nanomaterials in accordance with Article 16 of Regulation (EC) No. 1223/2009

Lamacoppa Leaf Sciences raw materials comply with Regulation (EC) No 1223/2009 of the European Parliament and the Council of 30 November 2009 on cosmetic products.

Introduction to CBD Isolate

CBD Isolate represents the zenith of purity in the realm of CBD raw materials and CBD products. It stands out as a 99% pure, non-psychoactive, white crystalline powder, meticulously refined to ensure the absence of THC and other cannabis plant compounds. Its unparalleled purity makes it an ideal choice for B2B companies looking for a versatile, THC-free CBD product.

Unveiling CBD Isolate

The journey from hemp cultivation to the final CBD crystalline powder involves a meticulous process to achieve the utmost purity and potency:

  • Cultivation: The process begins with the careful cultivation of hemp, ensuring a high-quality yield.
  • Extraction: Following harvest, crude oil is extracted from the biomass and flowers, capturing the essence of CBD.
  • Winterization: This step involves purifying the crude oil by removing unwanted substances such as waxes and lipids.
  • Distillation: The winterized oil undergoes distillation to further concentrate and refine the CBD oil.
  • Isolation: Through crystallization, pure CBD molecules are isolated to form the crystalline structure of the isolate.
  • Final Touches: The isolate undergoes filtration, washing, and drying to remove any remaining impurities, culminating in the packaging of the pure, white crystalline powder.

Frequently Asked Questions

Can I purchase CBD Isolate in bulk quantities?

Absolutely, our company specializes in providing bulk CBD Isolate to B2B companies. We pride ourselves on offering competitive pricing and a variety of bulk CBD solutions tailored to your business needs.

Does CBD Isolate contain any THC?

No, CBD Isolate is crafted from hemp and undergoes extensive purification to ensure it is free from THC, making it an ideal component for products requiring the benefits of CBD without the psychoactive effects.

What is the shelf life of CBD Isolate?

CBD Isolate boasts a commendable shelf life of up to 2 years when stored appropriately in a cool, dark environment, ideally within a temperature range of 68–77°F (20–25°C).

How does CBD Isolate differ from CBD Distillate?

CBD Isolate and Distillate differ significantly in appearance, composition, and cannabinoid content.

CBD Isolate is a pure, snow-white powder consisting solely of cannabidiol, whereas CBD Distillate, a golden-yellow extract, contains a broader spectrum of cannabinoids and terpenes, contributing to the entourage effect.

Distillate’s retention of minor cannabinoids and terpenes offers a distinct flavor and aroma, while Isolate is tasteless and odorless due to the removal of these compounds.

Is it possible to dissolve CBD Isolate in water?

CBD Isolate shares oil-like properties, making it naturally resistant to dissolving in water. However, advanced nanoemulsion techniques have been developed to enhance its water solubility.

Are there lab tests confirming the purity of CBD Isolate?

Indeed, despite its high purity level, we rigorously test our CBD Isolate at every production stage to guarantee its quality and purity. Each product comes with a Certificate of Analysis (COA) from an accredited third-party lab, ensuring it meets our high standards.

What is a Certificate of Analysis (COA)?

A COA is a detailed report from an independent laboratory that verifies the composition, potency, and purity of a product. It provides crucial information about a product’s cannabinoid profile and ensures consumer safety and confidence.

Are the COAs from accredited labs?

Yes, each COA is provided by ACCREDIA accredited, third-party laboratories, reflecting our commitment to transparency, quality, and consumer trust throughout the production process.

Is CBD Isolate more potent than other CBD forms?

When properly processed to achieve 99% or greater purity, CBD Isolate becomes the most potent form of CBD available. It is devoid of terpenes, flavonoids, and other hemp plant components, making it an ideal base ingredient or supplement for various cannabinoid products.

How can I request samples of CBD Isolate?

Samples are readily available upon request through our contact form. For detailed inquiries or to ensure the product meets your specific needs, we recommend reaching out via email to our dedicated team.

Do you offer discounts for bulk purchases of CBD Isolate?

Yes, we provide attractive volume discounts for our wholesale CBD Isolate purchases. Our sales team is ready to discuss our competitive pricing structure tailored to your order volume.

CBD Isolate offers unparalleled purity and versatility for B2B companies looking to incorporate high-quality CBD product into their product lineup.

Its THC-free composition, combined with our commitment to quality and customer service, makes it an ideal choice for businesses seeking reliable, pure CBD solutions.

Explore the potential of CBD Isolate and elevate your offerings with a product backed by rigorous testing and proven efficacy.

CBD Skin applications

In recent decades, the therapeutic potential of cannabinoids and analogous compounds has been intensively investigated. The endocannabinoid system has already been identified in the skin and, although much remains to be discovered about its contribution and  importance  for  the  maintenance  of  skin homeostasis, it has been increasingly associated as promising for dermatological disorders’ management.

Cannabidiol (CBD) has been shown to have hydrating, sebostatic, antipruritic, antimicrobial, anti- inflammatory, antioxidant, wound healing, photopro- tective, anti-fibrotic and antitumoral, as well as modulating hair growth. Thus, CBD has gained attention concerning its application in cutaneous pathologies such as atopic dermatitis, psoriasis, acne, epidermolysis bullosa, systemic sclerosis, seborrheic dermatitis, androgenetic alopecia and cutaneous melanoma, although its bioactivities still lack scientific evidence and some of its mechanisms of action remain to be elucidated.

Given its physicochemical characteristics, its topical administration becomes challenging, and it is necessary to develop new technological strategies to overcome the skin intact barrier. Different CBD delivery systems and formulation strategies that have been developed, studied, and implemented to improve the delivery of CBD in the skin.

Ancient medical patterns in the literature describe that cannabis has been used in different dermatological conditions for centuries.

Pre- clinical and clinical evidence about CBD applications and benefits have already begun to exist to treat several skin conditions.

CBD has different ways of reducing excessive skin water loss and, thus, increasing its water content. On one hand, CBD stimulates sphingomyelinase and consequently, by enhancing sphingomyelin (SGM) cleavage, rises ceramides levels, reinforcing the structure of the epidermis and preserving skin moisture. On the other hand, CBD has been shown to increase the expression of aquaporin-3 (AQP3) which, as it improves glycerol transport in different skin cells, improves skin water retention.

CBD Hair modulation action

CBD showed that when applied in different doses it presents different effects, probably mediated by two distinct receptors. On the one hand, at low concentrations, CBD promoted hair shaft elonga-tion without any influence on anagenesis/catagenesis nor the number of proliferating cells in human HFLs and downregulated pro-inflammatory cytokine levels, probably via ADR stimulation. On the other hand, at higher concentrations, it exhibited procatagenic activity, inhibited hair shaft growth and stimulated an increase in the number of cells in apoptosis, which seems to be associated with TRPV4. Also, adults diagnosed with androgenetic alopecia applied 3-4 mg of CBD in all their bald areas once a day for 6 months. At the end of this period, all together showed a 93.5% increase in hair count, supporting the idea that CBD has hair growth benefits. Despite all the data obtained, further studies are needed to establish the most advantageous topical dose of CBD for hair growth and the mechanism of action by which it exerts this activity.

CBD Sebostatic actions

Although what is known about the sebostatic properties of CBD is still scarce, the existing studies show promising results. The suppression of cellular proliferation is another CBD biological property that makes it a promising compound for the treatment of different dermatological conditions. In a study, CBD not only has suppressed their proliferation in vitro without diminishing cellular viability nor inducing apoptosis or necrosis, but it has also decreased MK167 expression, a proliferation marker (Olah et al. 2014). Moreover, a shampoo containing 0.075% broad-spectrum CBD applied for 14 days, has shown to have sebostatic activity in subjects diagnosed with mild to moderate scalp psoriasis or seborrheic dermatitis. Furthermore, a study to assess CBD effects on the sebaceous glands showed that CBD exerts sebostatic actions through ECS and non-ECS mechanisms, by having reversed the induction of lipogenesis by arachidonic acid and by a combination of linoleic acid and testosterone. CBD blocks the AEA TRP-stimulation of sebum production and activates TRPV4, the main TRP channel expressed in SZ95 sebocytes, which is responsible for its CBDs lipostatic action.

CBD Antipruritic actions

The anti-pruritic potential of CBD has been studied and is increasingly gaining attention given the successful, though limited, results that have been obtained.

A survey study was carried out to evaluate, in part, the types of cannabinoid-based medicines used and the evolution of symptoms in patients with epidermolysis bullosa. It was observed that the topical formulations were the most commonly adopted route of administration and that the most frequently used cannabinoid-based medicines were those combining THC with CBD (34.7%) and those containing only CBD (20.33%).

The antipruritic action of CBD was felt by the majority of patients (90.9%), who admitted to having had a significant improvement in pruritus and with more than half of them no longer have needed or have reduced anti-itch therapy doses. Also, a case report of a sublingual cannabinoid-based medicines containing CBD administrated to three patients suffering from epidermolysis bullosa has shown that together they experienced an effective improvement in the severity, intensity, and frequency of itching and a decrease in the urge to scratch. Supporting these observations regarding epidermolysis bullosa, a 10% CBD containing broad spectrum hemp oil, without THC, applied for a minimum of eight weeks in dogs diagnosed with Atopic dermatitits has been shown to decrease the intensity and recurrence of itching after just two weeks.

Although there are still no mechanistic or molecular studies reporting the effect of CBD on pruritus and the case reports that have been conducted lack scientific strength and statistical significance,   the CBD has the potential for further studies in this area.

CBD Antimicrobial actions

Although the antimicrobial activity of CBD has been described for some decades, it was only in 2008 that it began to be given proper attention, giving rise to further studies on account of its promising results. In different studies, CBD demonstrated a constant antibacterial activity against different Gram + bacteria, including multi-drug resistant strains and Propionibacterium acnes.

Also Gram- bacteria CBD showed consistent results among different studies, showing no antibacterial activity in at least 20 species, including Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter bau- mannii, except against Neisseria gonorrhoeae, N. Meningitidis, Moraxella catarrhalis and Legionella pneumophila, for which it appears to be a potent antibacterial compound. The mechanism of action by which CBD exerts its antibacterial activity is far from being fully understood. Notwithstanding, it has been described as a bactericidal agent with a low propensity to develop resistance that decreases membrane poten- tial

CBD Anti-inflammatory actions

The mechanisms by which CBD exerts its anti- inflammatory actions are not yet fully elucidated. However, by interacting with different receptors, CBD contributes to the decrease of general inflammatory conditions by reducing levels of numerous interleukines. Several animal studies have demonstrated the anti- inflammatory potential of CBD on the skin.

CBD Antioxidant actions

CBD antioxidant properties, just like anti-inflammatory ones, represent one of its main biological activities. Different in vivo and in vitro studies conducted on different keratinocyte cell lines and models, have demonstrated that CBD exerts its antioxidant actions through different mechanisms, all contributing to the decrease of the oxidative environment and the regulation of the redox balance. In this way, CBD has proven to have the ability to decrease the levels and activity of reactive oxygen species (ROS) generating enzymes, such as NADPH oxidase and xanthine oxidase.

Additionally, it also showed to be capable of upreg- ulating the activity of glutathione reductase and thioredoxin reductase, with a consequent increase in the levels of glutathione and thioredoxin, both compounds with important antioxidant activity. Complementing this mechanism of decreasing ROS levels, Hamelink et al. demonstrated that CBD also has the ability to reduce these reactive molecules by chelating transition metals required for their synthesis reaction.

CBD has also been shown to induce the expression of nuclear factor erythroid-2 related factor (NRF2), which is associated with the production of antioxidant and cytoprotective proteins and for which CBD has shown to be an activator . Thus, by decreasing the production and levels of ROS and pro-oxidant factors and by increasing molecules, receptors, and enzymes that contribute to a general anti- oxidant action in keratinocytes, CBD prevents oxidative stimuli-induced alterations in membrane phospholipids, such as the production of lipid peroxidation products. In this way, CBD contributes to preventing the formation of adducts with proteins, which allows for keeping intact and functional different proteins that are important for the maintenance of cellular homeostasis, such as chaperones.

CBD Wound healing actions

Wound healing is an innate process that allows a prompt and efficient tissue damage and rehabilitation. It results from an interaction between different cells, growth factors, and various mediator substances and it occurs in a sequential way that includes three main phases. CBD is being study as a potential new therapy molecule to accelerate wound healing. The activity of a C. sativa L. ethanolic extract and pure CBD on the expression of wound healing relevant genes was evaluated. Scientific studies concluded that CBD has the ability to act against pro-inflammatory mediators associated with wound healing, favoring this process, but there are other compounds in cannabis that act synergistically to obtain better results. However, the activity of CBD in wound healing was also observed by Zheng et al. who developed a hydrogel containing CBD and studied its healing ability in SD

CBD Photoprotection actions

UV radiation comprises, not only but also, UVA and UVB radiation, the major radiation types causing damage to skin cells. CBD has multiple properties that make it a potential molecule to counteract radiation damage in skin cells. These include the capacity to reduce ROS levels, regulate antioxidants and oxidative molecules to optimum levels, modulate the immune system and avoid exacerbated inflammatory responses. Its capacity of reducing the oxidative stress state stems from its regulation of ROS not only by trapping them, chelat- ing essential metal ions or by stimulating antioxidant enzymes involved in their metabolization, but also by regulating cannabinoid receptors activity.

In a Nutshell 

CBD is making waves in the world of skin care, with a host of potential benefits that could revolutionize how we approach skin health. While the science is still catching up, the future looks promising for CBD as a natural, versatile addition to our skin care routines.

Rif.: Skin applications of cannabidiol: sources, effects, delivery systems, marketed formulations and safety. 

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